IVER-ON™
IVERMECTIN POUR-ON for cattle
Contains 5 mg ivermectin/mL
Parasiticide
Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
ANADA 200-299, Approved by FDA.
Introduction:
Ivermectin Pour-On delivers internal and external parasite control in one convenient low-volume application. Discovered and developed by scientists from Merck Research Laboratories, Ivermectin Pour-On contains ivermectin, a unique chemical entity.
Indications:
Ivermectin Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites.
Gastrointestinal Roundworms
Ostertagia ostertagi (including inhibited stage) (adults and L4), Haemonchus placei (adults and L4), Trichostrongylus axei (adults and L4), T. colubriformis (adults and L4), Cooperia oncophora (adults and L4), Cooperia punctata, Cooperia surnabada, Strongyloides papillosus (adults), Oesophagostomum radiatum (adults and L4), Trichuris spp. (adults)
Lungworms: Dictyocaulus viviparus (adults and L4)
Cattle Grubs: (parasitic stages) Hypoderma bovis, H. Lineatum
Mites: Sarcoptes scabiei var. bovis
Lice: Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenopotes capillatus
Horn Flies
Haematobia irritans
Persistent Activity
Ivermectin Pour-On has been proved to effectively control infections and to protect cattle from reinfection with Ostertagia ostertagi, Oesophagostomum radiatum, Haemonchus placei, Trichostrongylus axei, Cooperia punctata and Cooperia oncophora for 14 days after treatment.
Treatment of Cattle for Horn Flies
Ivermectin Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results Ivermectin Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.
Dosage
The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.
Administration
Squeeze-Measure-Pour System (8.5 fl. oz/250 mL Bottle with 25 mL Measuring Cup). Measure the amount of solution to be used at the dose rate of 1 mL for each 22 lb of body weight into the measuring cup. When body weight is between markings use the higher setting.
Tilt the measuring cup to deliver the dose.
Squeeze-Measure-Pour System (33.8 fl. oz/1 L Bottle with 25 mL Measuring Cup). Measure the amount of solution to be used, at the dose rate of 1 mL for each 22 lbs of body weight, into the measuring cup. When body weight is between markings, use the higher setting.
Tilt the measuring cup to deliver the dose.
Collapsible Pack (84.5 fl oz/ 2.5 L Pack and 169 fl. oz./5 L Pack). Connect the applicator gun to the collapsible pack as follows: Attach the open end of the draw-off tubing to the dosing equipment. Replace the shipping cap with the draw-off cap and tighten down. Attach draw-off tubing to the draw-off cap.
Gently prime the applicator gun, checking for leaks.
Follow the manufacturer's directions for adjusting the dose.
When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container. To prevent removal of special lubricants form the Protector Drench Gun, the gun and tubing must not be washed.
Mode of Action
Ivermectin as a member of the avermectin family kills certain parasitic roundworms and ectoparasites, such as mites, lice, horn flies and other insects. Its action is unique to the avermectin class of antiparasitic agents. This action involves a chemical that serves as a signal from one nerve cell to another, or from a nerve cell to a muscle cell. This chemical, a neurotransmitter, is called gamma-amino-butyric acid or GABA.
In roundworms, ivermectin stimulates the release of GABA from nerve endings and enhances binding of GABA to special receptors at nerve junctions, thus interrupting nerve impulses - thereby paralyzing and killing the parasite.
The enhancement of the GABA effect in arthropods such as mites, lice and horn files resembles that in roundworms except that nerve impulses are interrupted between the nerve ending and the muscle cell. Again, this leads to paralysis and death.
Ivermectin has no measurable effect against flukes or tapeworms, presumably because they do not have GABA as a nerve impulse transmitter.
The principle peripheral neurotransmitter in mammals, acetylcholine, is unaffected by ivermectin. Ivermectin does not readily penetrate the central nervous system of mammals where GABA functions as a neurotransmitter.
Safety
Studies conducted in the USA have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.
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RESIDUE INFORMATION: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. |
WARNING! NOT FOR USE IN HUMANS.
This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.
Keep this and all drugs out of the reach of children.
WARNING! FLAMMABLE!
KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME AND OTHER SOURCES OF IGNITION.
PRECAUTIONS
Store away from excessive heat (104°F/ 40°C) and protect from light.
Use only in well-ventilated areas or outdoors. Close container tightly when not in use.
Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced. Do not use when rain is expected to wet cattle within six hours after treatment.
This product is for application to skin surface only. Do not give orally or parenterally.
Cloudiness in the formulation may occur when Ivermectin Pour-On is stored at temperatures below 32°F. Allowing to warn at room temperature will restore the normal appearance without affecting efficacy. Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g. caked mud or manure.
Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, Ivermectin Pour-On is not recommended for use in species other than cattle.
When to Treat Cattle with Grubs
Ivermectin Pour-On effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season. While this is not peculiar to ivermectin, destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable hostparasite reactions. Killing Hypoderma lineatum when it is in esophageal tissues may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis. Cattle should be treated either before or after these stages of grub development.
Cattle treated with Ivermectin Pour-On at the end of the fly season may be re-treated with ivermectin during the winter without danger of grub-related reactions. For further information and advice on a planned parasite control program, consult your veterinarian.
Environmental Safety
Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain aquatic organisms. Do not permit cattle to enter lakes, streams or ponds for at least six hours after treatment. Do not contaminate water by direct application or by the Improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration.
Package Information
Ivermectin Pour-On is available in an 8.5 fl. oz./250 mL bottle, a 33.8 fl. oz/1 L bottle, an 84.5 fl. oz/2.5 L collapsible pack and a 169 fl. oz/ L collapsible pack intended for use with appropriate automatic dosing equipment.
NAC No.: 10270153
